Celtics vs. Pistons NBA expert prediction and odds for Friday, March 22 (Lay it with Boston)

Betting odds, pick and prediction for the Boston Celtics' matchup with the Detroit Pistons on Friday, March 22.

Boston Celtics guard Payton Pritchard.
Boston Celtics guard Payton Pritchard. / David Butler II-USA TODAY Sports

The Boston Celtics are looking for another win this week against the Detroit Pistons, who have lost four games in a row, including three by double digits.

Boston is favored by 14 points in this game, and they may not be enough after the team dominated Detroit at TD Garden, winning 119-94 on Monday night.

Cade Cunningham is expected to return for the Pistons after missing Monday’s game, but can he make the difference for Detroit? 

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Let’s break down the odds and my best bet for this contest: 

Celtics vs. Pistons odds, spread and total

Celtics vs. Pistons how to watch

  • Date: Friday, March 22
  • Time: 7:00 p.m. EST
  • Venue: Little Caesars Arena
  • How to watch (TV): NBC Sports Boston, Bally Sports Detroit
  • Celtics record: 55-14
  • Pistons record: 12-57

Celtics vs. Pistons injury reports

Boston Celtics injury report

  • Jaylen Brown – questionable
  • JD Davison – out
  • Sam Hauser – probable
  • Jrue Holiday – out
  • Al Horford – questionable
  • Kristaps Porzingis – questionable
  • Jayson Tatum – questionable

Detroit Pistons injury report

  • Simone Fontecchio – out
  • Taj Gibson – out
  • Stanley Umude – out
  • Ausar Thompson – out
  • Quentin Grimes – out
  • Isaiah Stewart – out

Celtics vs. Pistons key players to watch

Boston Celtics

Jayson Tatum: If he plays, Tatum could be in line for a big game against a Pistons defense that allowed Jaylen Brown to score 31 points in 30 minutes on Monday. Tatum is averaging 27.1 points, 8.3 rebounds and 4.9 assists per game on the season, scoring 30 or more points in three of his last four games. 

Detroit Pistons

Cade Cunningham: Cunningham missed the Monday matchup with Boston, but he turned in a big performance on Tuesday against the Indiana Pacers. The Pistons guard had 23 points, six rebounds and 10 assists on 9-of-22 shooting in just 29:03 of game time. 

Celtics vs. Pistons prediction and pick

I’m going to lay the points with Boston here, as the Celtics are now over. 500 on the season when it comes to them being favored on the road (15-14-3 ATS). 

The Pistons, on the other hand, are just 14-14-1 against the spread as home dogs. This could be a spot to back Boston -- if most of the team's roster suits up. Jayson Tatum, Jaylen Brown and Kristaps Porzingis are questionable for this game while Jrue Holiday has been ruled out. 

Still, Boston didn’t even need Tatum to win by 25 points in the last meeting between these teams, and the Pistons are down several key rotation players including Quentin Grimes, Isaiah Stewart and Ausar Thompson. 

Plus, Boston has covered as a road favorite on four straight occasions. Lay the points here. 

Game odds refresh periodically and are subject to change.

Find Peter Dewey's NBA betting record here (futures included). You can also follow my daily plays on BetStamp here.